This Week in Startups

This Week In Startups is made possible by: Plaud - https://plaud.ai/twist Sentry - https://sentry.io/twist Lightfield - https://lightfield.app Rippling - https://rippling.ai/twist Today’s show: Is OpenAI finally priced correctly? Jason argues that the reported $30 billion raise at a $1.25 trillion valuation is finally “right-sized.” He also says that he’d put money in at that price, while walking through the risks that could still sink the investment. It’s a Friday all-news episode with Jason and Lon, covering OpenAI’s latest round, SpaceX’s push to become America’s fourth major carrier, Zuck and Meta’s creative move around the proposed California billionaire tax, and some of Lon and Jason’s favorite documentaries. Plus we’re asking the timely question: who watches the AI watchdogs? Relevant Links OpenAI nears up to $30B round at $1.25T valuation, led by UAE investors (CNBC): https://www.cnbc.com/2026/10/22/openai-funding-round-uae-investors.html Anthropic investors eye a $2T IPO (Nasdaq):…

This Week In Startups is made possible by: DigitalOcean - Head to https://do.co/twist to start building on DigitalOcean's AI-Native Cloud today — and cut your AI workload costs by up to 50% Odoo: The all-in-one business platform. Your first app is free! Get started today at https://odoo.com/twist Thanks to our partners at Rippling! Head to https://rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! Today’s show: Elizabeth Holmes remains in prison for defrauding Theranos investors, even as she stars in the hit Nathan Fielder/Lance Oppenheim documentary “You Can See Everything.” But we’re asking the real question: After all the very public accusations… the hit pieces in the press and the Hulu drama series picking apart the scandal… would…

This Week In Startups is made possible by: Plaud: https://plaud.ai/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Vanta: https://www.vanta.com/twist Rippling: https://rippling.ai/twist Today’s show: Jason can’t stop praising Nathan Fielder’s new A24 hybrid documentary about Elizabeth Holmes and Theranos, “You Can See Everything,” and he’s insisting that Lon check it out before the next podcast. Hear his spoiler-free review, how the film upended his expectations based on Fielder’s previous work, and why Lon also recommends Lance Oppenheim’s HBO Max series “Ren Faire.” Plus, we’re talking to Clone Robotics co-founder and CEO Dhanush Radhakrishnan about why he thinks robots should not just be humanoid but should look and move precisely like humans. We’re digging deep into how his hydraulic myofiber artificial muscle technology alters and even improves on the pulley-based systems being deployed by competitors, why he thinks the models that power domestic helper-bots will…

This Week In Startups is made possible by: Lightfield: https://lightfield.app Every.io: https://every.io/ PayPal: https://paypal.com/business Plaud: https://plaud.ai/twist GoDaddy: https://www.godaddy.com/ Today’s show: Today’s college grads are showing up to work at Jason’s company unable to write three sentences. He’s asking what Shishir Mehrotra of Superhuman, the company behind Grammarly, can do to fix that. Shishir delves into Superhuman’s reasons for acquiring GPTZero, the most popular AI detector, and the AI notetaker Fathom, and the spreadsheet startup Rows. Plus, how Shishir responds to accusations that Grammarly helps students cheat in the classroom, why writers should disclose when they’re collaborating with an LLM, and Jason's CEO wish list for fresh Grammarly features. In the news, Tesla demoed its long-awaited Roadster, which used SpaceX thrusters to do some flips and propel itself over five other Teslas… And OpenAI warned staffers that spies may be trying to seduce them in order to steal…

This Week In Startups is made possible by: Paper: https://getpaper.ai/twist Superhuman: https://superhuman.com/ Odoo: https://Odoo.com/twist Today’s show: Misha Laskin of Reflection AI joins Jason to explain why big companies are done renting their AI from closed labs. Enterprises want to keep their data, cut their costs, and tune their models to their unique businesses. Reflection is launching its first open-weight model, Beam, just three months after acquiring its first big cluster. Misha admits that Beam trails the best Chinese open models by a couple of months, and needs 3 to 4 times fewer tokens to reach the same answer, but nonetheless, the race is on. PLUS, Misha explains how “reward hacking” led that rogue OpenAI model to break out of its test sandbox and steal the answers from Hugging Face's servers. The model solved the problem, just not the way anyone intended. There’s simply no way a few hundred safety researchers at closed labs can catch every flaw; open source is how software has always been…

This Week In Startups is made possible by: Plaud: https://plaud.ai/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain NetSuite: https://netsuite.ai/twist The Conservation Fund: https://conservationfund.org Today’s show: At packed concerts, festivals, and stadiums, your phone gets WORSE with every person who shows up. Totem gets better. Carter Fowler of Totem joins Alex to explain how his screen-free compass points you straight to your friends without relying on cell towers. Find out why Carter says Apple will never ship this in an iPhone, and why kids, ski patrols, and blind users have become some of his most loyal fans. PLUS, Lon and Alex dig into the archives for Jason's 2017 CES interview with Ring founder Jamie Siminoff, a year before Amazon bought the company. Jamie explains how a doorbell he couldn't hear in his garage became Ring, and why a strong mission is "cheating" when it comes to keeping a team focused. Then he tells Jason he wants to take Ring public, not…

This Week In Startups is made possible by: Lightfield: https://lightfield.app Rippling: https://Rippling.ai/twist Upwork: https://upwork.com Today’s show: AssetHub built an AI agent that recreates licensed characters in 3D while respecting copyright rules... But Jason says he needs to think BIGGER. 11 founders pitched their companies to Jason and Yuki Shirato of Techstars Tokyo at our Osaka event this week, and neither investor held back. Find out why Jason says Seekr feels more like a vitamin than a painkiller, and needs to ditch the press mentions from their deck. Plus, a vital lesson for founders: if everyone already knows about the problem you're solving, investors expect a tight solution and business plan. Truly novel business ideas get more leeway. Japan's startup community is booming, with many recent grads bailing on lifelong gigs at major corporations to start companies. But here's why Yuki says the fear of failure is still holding back progress. Guests: Yuki Shirato on LinkedIn:…

This Week In Startups is made possible by: Plaud: https://plaud.ai/twist Odoo: https://odoo.com/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Quo: https://www.quo.com/perks/twist Today’s show: A personal AI agent that’s still invite-only just hit a $10 billion valuation. Guest host Deedy Das of Menlo Ventures is joined by Kanu Gulati of Khosla Ventures, Chris Farmer of SignalFire, and Sheel Mohnot of Better Tomorrow Ventures to debate whether Instinct can beat Meta’s Muse, what they actually use their own agents for, and what breaks when everyone’s agent makes the same move. Plus we’re also talking about OpenAI’s math breakthroughs, the Factory vs. Cognition fight, and whether SaaS is still worth funding. Catch the whole debate on this week’s VC roundtable. Guests: Deedy Das on X: https://x.com/deedydas Menlo Ventures: https://menlovc.com Kanu Gulati on X: https://x.com/KanuGulati Khosla Ventures: https://www.khoslaventures.com Chris Farmer on X:…

This Week In Startups is made possible by: Vanta: https://www.vanta.com/twist DigitalOcean: https://do.co/twist Sentry: https://sentry.io/twist Plaud: https://plaud.ai/twist Today’s show: The smarter AI gets, the more it just does the work for you, and the less helpful it becomes as a tutor. Shan Reddy of Aristotle joins Jason to demo a voice-first tutor built to run a session the way a $200-an-hour human tutor would. We also dive into why frontier models are trained to hand you answers rather than build real understanding. PLUS, in Ask Jason, an incoming Fordham student (Jason’s alma mater!) wants to prepare for a career in finance. Plus, David from NYU calls back and wants to discuss what everyone would do with $500K in free money. Then, why does Jason think the Doomerism is coming from inside the AI labs? Guests: Shan Reddy on X: https://x.com/rshanreddy Aristotle: https://www.heyaristotle.com/ Relevant Links: Shoe Dog by Phil Knight → https://en.wikipedia.org/wiki/Shoe_Dog Something Like an Autobiography…

This Week In Startups is made possible by: Every.io: https://every.io/ Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Odoo: https://odoo.com/twist Plaud: https://plaud.ai/twist Today’s show: What can AI do with the guardrails OFF? Devon Thomas of Abliteration.ai thinks defenders should have access to the same kinds of tools, rather than having one hand tied behind their backs. Then, on Ask Jason, learn what AI means for the billable hour from a legal-tech founder. PLUS, are AI microdramas a real ecosystem or a fad, and does AI finally make solo founders fundable? Guests: Devon Thomas on X: https://x.com/founderengineer Abliteration: https://abliteration.ai/ Relevant Links: Abliteration.ai on a16z speedrun — the accelerator Jason congratulated Devon on → https://speedrun.a16z.com/companies/abliteration TechCrunch: "Abliteration.ai is making a business out of removing AI guardrails" — the coverage behind the recent attention →…

This Week In Startups is made possible by: Plaud: https://plaud.ai/twist CLA: https://www.claconnect.com/withyou Sentry: https://sentry.io/twist Lightfield: https://lightfield.app Today’s show: Google once interviewed the entire Justin.tv (now Twitch) team and then walked away from an acquisition deal, saying they weren’t good enough. Seven investors passed on buying 10% of Airbnb for $150,000, a stake pegged at roughly $9.25 billion today. Lon Harris and Alex Wilhelm revisit classic TWiST interviews with Justin Kan of Twitch and Brian Chesky of Airbnb to find out what those founders understood that the market didn't. PLUS, how did a box of cereal win over Paul Graham and get Airbnb into Y Combinator? Flashback Guests: Justin Kan on X: https://x.com/justinkan Twitch: https://www.twitch.tv/ Justin Kan (@justinkan) on X Brian Chesky on X: https://x.com/bchesky AirBnB: https://www.airbnb.com/ Relevant Links: TWiST E900: Justin Kan, co-founder of Justin.tv, Twitch & Atrium (Feb 5, 2019) →…

This Week In Startups is made possible by: Every.io: https://every.io/ Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Sentry: https://sentry.io/twist Today’s show: A product that would have cost $500,000 to build in 2006 now costs less than a used car. Jason put up $5,000 on an idea he'd been sitting on for 20 years, and so far, we’ve received dozens of amazing submissions from vibecode experts. See how well the Top 3 demos fare, and which app was so good, Jason’s already thinking about spinning it off into a startup. PLUS, an unhoused founder calls in asking how to raise money for not one but two pre-revenue startups? Hear Jason and Lon’s advice. Submissions: Submission 1 — https://annotated.wtf By Robert Submission 2 — https://annotated.bytetalk.ai/feed By Alan Shiflett Alan on X: https://x.com/alanshiflett Submission 3 — https://anotated.com/ By Chirag Asarpota Chirag on X: https://x.com/ChiragAsarpota Relevant Links: annotated.com bounty brief —…

This Week In Startups is made possible by: PayPal: https://paypal.com/business Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Odoo: https://Odoo.com/twist Today’s show: Wall Street suspects new Apple CEO John Ternus may do something predecessor Tim Cook almost never did: writing a huge check. So Jason and Lon are playing “fantasy draft” with Apple’s balance sheet, choosing five real companies to acquire over five “rounds.” Disney buys them a ton of IP and unlocks theme park synergies. Sony gets them a gaming console and massive anime distribution. Boston Dynamics buys them lots of robots, while Etched nets them cheaper inference. So many options! Then, we chat with Stacy Salvi of The90. Her wearable pendant tells you exactly how much sun damage you’re accumulating, long before you start to burn. Guest The90: https://the90.com/ Stacy Salvi on LinkedIn: https://www.linkedin.com/in/stacysalvi/ Relevant Links John Ternus becomes Apple CEO:…

This Week In Startups is made possible by: Lightfield: https://lightfield.app Paper: https://getpaper.ai/twist The Conservation Fund: https://conservationfund.org/ Plaud: https://plaud.ai/twist Athena: https://www.athena.com/jcal Today’s show: An OpenAI agent breached Australia's Medicare statistics portal in June, and it took 84 days for the Frontier Lab to publicly acknowledge it. Jason and Lon dig into whether this is an important cautionary tale about alignment, or if PM Anthony Albanese looking to join the AI conversation. Then Bryant Chou of Ploy joins to explain skipping pre-seed and seed entirely to raise $27M, and why he’s taking his time to build his all-in-one agentic solution for running businesses. Learn why Google is launching four TPUs into orbit for Project Suncatcher. PLUS, how many robots a week is Tesla now shipping with Optimus, and Jensen Huang told Ezra Klein basic math no longer matters. Is he right? Can we forget long division, at last? Guests: Bryant Chou on X:…

This Week In Startups is made possible by: Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Odoo: https://odoo.com/twist Rippling: https://rippling.ai/twist Plaud: https://plaud.ai/twist Harmonic: https://harmonic.ai/twist Today’s show: Anthropic and OpenAI released cheaper models on the same day with Claude Opus 5.5 and GPT-6, and these VCs would still bet on open source. Jason brings on Dave McClure of Practical Venture Capital, Jeff Clavier of Uncork Capital, and Jenny Fielding of Everywhere Ventures to discuss the argument for open-weight models over the frontier labs. Learn why median seed valuations have more than tripled since 2017. Why does Dave say it's a buyer's market for secondaries right now? PLUS, does Meta's Muse leave any room for Instinct, and why are fintech and healthcare suddenly out of favor? Guests: Dave McClure on X: https://x.com/davemcclure?lang=en Practical Venture Capital: https://practicalvc.com/ Jeff Clavier on X: https://x.com/jeff Uncorked…

This Week In Startups is made possible by: Vanta: https://www.vanta.com/twist DigitalOcean: https://do.co/twist Lightfield: https://lightfield.app Plaud: https://plaud.ai/twist Today’s show: Elon revives the Hyperloop, promising a 30-minute commute between Austin and San Antonio. It's the kind of project that could reshape how Texans think about getting between two major cities entirely. Then, Jason and Lon explain why this pitch is different from the other Boring Company tunnels. Learn why President Trump wants to rename artificial intelligence itself and launch an "AI Force." It's a move that could reshape how the government talks about AI policy going forward. PLUS, a new startup's model refuses to write a single word of text, and it is 5 to 18 times faster with better accuracy. It's a completely different approach to how AI agents make decisions, and it might be a preview of where the industry heads next. Relevant Links: "Elon Musk's latest Boring Company pitch involves a Hyperloop between Austin and San…

This Week In Startups is made possible by: Superhuman: https://superhuman.com/ Paypal: https://paypal.com/business Odoo: https://odoo.com/twist Plaud: https://plaud.ai/twist Harmonic: https://harmonic.ai/twist Today’s show: Hugging Face built a $399 open-source robot duck as a side quest, and sold 16,000 units off a single tweet. Co-founder Thomas Wolf joins Jason and Lon to explain Microduck happened, why storage is the company's real business, and what it felt like to get hacked by OpenAI's agents. Jason takes apart Gavin Newsom's new AI "kill switch" executive order: if these models are so dangerous, why not start with the same KYC every bank already requires? PLUS, Snap’s new AI-integrated glasses could be a game-changer. Guests: Thomas Wolf on X: https://x.com/Thom_Wolf Hugging Face: https://huggingface.co/ Relevant Links: Hugging Face — https://huggingface.co/ Microduck — https://pollen-robotics.com/microduck/ Pollen Robotics — https://pollen-robotics.com/ OpenAI: the Hugging Face incident and the road…

The TWiST AI Basics series is made possible by Google for Startups! Build context-aware AI workflows using DeepMind models and orchestration tools with Google for Startups' new Startup technical guide on generative media. Get the guide here: https://goo.gle/technical_guide Today's show: The demo works, the vibes are immaculate, but then the app falls apart the second real users touch it. On today's AI Basics, Temporal co-founder and CEO Samar Abbas says the problem isn't with the model at all. You're missing a harness, the layer that keeps an AI agent's work durable, secure, and recoverable if/when something breaks. Temporal's durable execution platform is used by major companies from OpenAI to Stripe to Netflix, and helps to make their long-running software reliable and interruption-free. On AI Basics, he explains why so many AI-coded prototypes die in the imagineering stage, before ever hitting production. Plus he walks Jason through Temporal's live dashboard, to show how it gives developers full…

This Week In Startups is made possible by: Quo: http://quo.com/TWiST The Conservation Fund: https://conservationfund.org CLA: https://www.claconnect.com/withyou Today's show: A 27-year-old Anthropic researcher quit last week warning that AI could cause human extinction, and by Friday, a caller's 76-year-old mother was texting her in a panic. Jason's answer: the labs are already shipping the safeguards Doomers say don't exist. On an all live calls episode of TWiST, learn about the AI implications Jason is actually scared of, and why it involves a terrorist cell and a thousand cheap drones. PLUS, who is liable when one AI prompts another AI into launching a meme coin, and can a 1.5-3 megawatt cannabis facility be converted into a data center? Relevant Links: Anthropic Resignee — https://www.nbcnews.com/tech/tech-news/anthropic-safety-researcher-resigned-warning-rapid-ai-development-gamb-rcna596767 OpenAI's Navier-Stokes claim— https://www.science.org/content/article/how-ai-math-breakthrough-ignited-controversy…

This Week In Startups is made possible by: DigitalOcean: https://do.co/twist Odoo: https://odoo.com/twist Upwork: https://upwork.com Today's show: The Pentagon is reportedly in talks to lend AI cloud startup Fluidstack $5. billion, and Jason thinks the real story isn't the loan itself. It's the US government owning equity in private AI companies, and competing directly with venture capital. Plus returning friend of the pod Tibo Louis-Lucas shows us how he runs seven companies with fewer than 10 people by stacking AI agents. Can a few $200/month AI subscriptions really do the work of an entire marketing team? Tibo seems to think so. Plus it's Off-Duty Friday, so Jason and Lon are reviewing some current streaming favorites, and commemorating the 25th anniversary of 9/11 with some personal stories. Check out the full summary and transcript of today's episode from Plaud: https://plaud.ai/twist Guests: Tibo Louis-Lucas on X: https://x.com/tibo_maker Squad: https://squad.so/ Relevant Links: Fluidstack:…

This Week In Startups is made possible by: Wilson Sonsini: https://www.wsgr.com/en/ Today's show: One of YouTube's three co-founders left for grad school and walked away with a fraction of what his partners made on the Google sale. Becki DeGraw of Wilson Sonsini joins Jason for Startup Legal Basics to explain the vesting schedule behind that gap, and why you want one even if you never take a dollar of venture money. Learn how VCs actually respond when a founder says "I've already put in four years," and the exact language Jason gives founders to turn one term sheet into three. PLUS, why is an inactive advisor still vesting your equity, and who wrote those performance milestones? Guests: Becki DeGraw on LinkedIn: https://www.linkedin.com/in/rebecca-degraw-639bbb62/ Wilson Sonsini: https://www.wsgr.com/en/ Relevant Links: Becki DeGraw — partner in WSGR's San Francisco office — https://www.wsgr.com/en/people/becki-degraw.html TechCrunch broke the YouTube story—…

This Week In Startups is made possible by: Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain NetSuite: https://www.netsuite.ai/twist Vanta: https://www.vanta.com/twist Plaud: https://plaud.ai/twist Today's show: An Anthropic researcher quit this week, saying both leading labs are gambling with everyone's lives. His coworker chimed in and predicts there is a greater than 10% chance that AI will end humanity IN THE NEXT 10 YEARS. Jason and Lon take it to Yohei Nakajima of Untapped Capital, Ben Lerer of Lerer Hippeau, and Rebecca Lynn of Canvas Prime, who cannot decide whether it is the greatest PR strategy in history or some kind of mass psychosis. Learn why Jason says founders should never hand a frontier lab their proprietary data, whether or not they're offered free credits. PLUS, who really solved Navier-Stokes, and what does the OpenAI–Buckmaster fight mean for anyone doing real work inside ChatGPT or Claude? Guests: Yohei Nakajima on X: https://x.com/yoheinakajima Untapped…

This Week In Startups is made possible by: Odoo: https://odoo.com/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Rippling: https://rippling.ai/twist Today's show: Your doctor almost certainly isn't testing your insulin. Dr. Mark Hyman sits down with Jason to explain the broken system that Function is fixing, and what 100 million biomarkers say about how sick America actually is. Learn why insulin beats blood sugar as an early warning for TKTKTK. Why might "normal" lab ranges be unreliable? PLUS, how does an expert like Dr. Hyman feel about GLP-1s and psychedelics? Guests: Dr. Mark Hyman on X: https://x.com/drmarkhyman Function: https://www.functionhealth.com/ Relevant Links: The Dr. Hyman Show — https://podcasts.apple.com/us/podcast/the-dr-hyman-show/id1382804627 Function pricing — https://www.functionhealth.com/pricing Ezra — the full-body MRI company Function acquired https://ezra.com/ Galleri (GRAIL) — the multi-cancer early detection blood test —…

This Week In Startups is made possible by: Wilson Sonsini Today's show: Spinouts are everywhere right now, and most founders get the cap table wrong. Jason sits down with Becki DeGraw, partner at Wilson Sonsini, to break down how to do it right, starting with his 80/20 rule for splitting the new cap table and why letting the old company keep too much of it kills your ability to raise. Becki also covers the legal side: who owns the IP, non-competes between the two companies, and the trap founders fall into when they're still on the old board. PLUS, the one question every Series A investor will ask. Guests: Becki DeGraw on LinkedIn: https://www.linkedin.com/in/rebecca-degraw-639bbb62/ Wilson Sonsini: https://www.wsgr.com/en/ Relevant Links: Wilson Sonsini Goodrich & Rosati (WSGR) — **https://www.wsgr.com/** Becki DeGraw — https://www.wsgr.com/en/people/becki-degraw.html Waymo — Jason's headline example of a big-company spinout — https://waymo.com/ Expedia's 1999 Microsoft spinout —…

VC experts on why Physical AI funding is heating up | E2333 This Week In Startups is made possible by: partner 1 - link partner 2 - link partner 3 - link Today's show: Are we one step closer to data centers in space? Katelin Holloway of Seven Seven Six and Paige Doherty of Behind Genius Ventures break it down what it would take. Plus investor interest is surging in Physical AI companies. Paige explains why she backs applications of physical AI over general-purpose robotics, and how her thesis on multimodal AI led to the largest check she's ever written. We then dive into the Pentagon's rollout of ChatGPT Mil and Grok for Government. And Katelin gives us her insight into how VCs are investing in Europe and the regulations behind the scenes. Guests: Katelin Holloway on X: https://x.com/katelin_cruse Seven Seven Six: https://sevensevensix.com/ Paige Doherty on X: https://x.com/paigefinnn Behind Genius Ventures: https://www.behindgeniusventures.com/ Full Transcript and Summary, powered by Plaud…

This Week In Startups is made possible by: Northwest Registered Agent: https://northwestregisteredagent.com/twistdomain CLA: https://www.claconnect.com/withyou Rippling: https://rippling.ai/twist Today's show: Hugging Face's $399 Microduck and the art of companies taking on side quests. Then, we get into Dwarkesh Patel's "The Rise and Fall of Agent Civilizations," which blew up online this weekend. Jason calls the "secret AI civilization" framing deliberate PR, and thinks it's inflammatory enough that someone might attack a data center over it. Then, Anders Forslund of Heart Aerospace shows off the X1, a battery-powered electric airliner designed for regional flights that can fly for 30 minutes on just $5 of juice. PLUS, we've got John Yu of Bitsec explaining how his subnet project outperformed Fable 5 in website vulnerability checks. Guests: Anders Forslund on X: https://x.com/AndersForslund1?s=2 Heart Aerospace: https://www.heartaerospace.com/ John Yu on X: https://x.com/yubrew Bitsec: https://sentios.io/…

This Week In Startups is made possible by: DigitalOcean: https://do.co/twist Every.io: https://every.io PayPal: https://paypal.com/business Today's show: *Nvidia agreed to buy Hugging Face for $12.9 billion, just days after quietly licensing Poolside's coding model for $6 billion+. On TWiST, Jason lays out why this is actually the biggest AI story of the year. Nvidia plans to offer enterprises unmetered, unlimited on-prem compute, pulling them away from reliance on Anthropic and OpenAI's frontier models and products. PLUS we're chatting with Halter founder & CEO Craig Piggott about how his company helps farmers optimize their land use via solar-powered AI-driven cattle collars. AND Hop Aero CEO and co-founder Matija Milenovic shows us Rook, his autonomous hypersonic cargo rocket that can launch from a shipping container and deliver cargo up to 450 miles away in about 15 minutes. Finally, Jason and Lon explain why you never post Slop on the timeline. Guests: Craig Piggott on X: https://x.com/craig_piggott…

This Week In Startups is made possible by: Lightfield: https://lightfield.app Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Rippling: https://Rippling.ai/twist Today's show: *Bill Gates dropped a 6,000 word warning: AI will be "the greatest equalizer ever invented, or the worst sort of injustice." The Microsoft icon has an AI agenda for the US: new national institutions, AI use taxes, and jobs legally reserved for humans only. Our VC roundtable guests — Sheel Mohnot (Better Tomorrow Ventures), Dave McClure (Practical Venture Capital), and Hussein Kanji — push back hard. Is taxing profits a better fix for AI taking jobs than taxing the tokens themselves? PLUS: Meta's $17B kids safety settlement… does it go far enough? Why does Stripe want OpenRouter? A peek at the VC's actual portfolio mark-ups. AND begun, the AI agent wars have. Our panel chooses between OpenClaw, Instinct, and Grok Bot. Guests Sheel Mohnot on X: https://x.com/pitdesi Better Tomorrow Ventures:…

This Week in Startups is brought to you by… LinkedIn Ads. To redeem a $100 LinkedIn ad credit and launch your first campaign, go to http://www.linkedin.com/thisweekinstartups Zendesk. A service-first CRM company with support, sales, and customer engagement products designed to improve customer relationships. Qualifying startups can join the Zendesk for Startups Program and get six free months of Zendesk products. Visit https://zendesk.com/startups today to get started. Beehiiv. Power your newsletters with AI tools, referral programs, and ad network features—all in one platform. Get 30 days free and 20% off your first 3 months at https://www.beehiiv.com/twist * Todays show: Alex is joined by Joff Redfern and Derek Xiao of Menlo Ventures to discuss the significant role AI plays in modern workflows. We look behind the numbers of their recent report: "2024: The State of Generative AI in the Enterprise" while exploring AI spending trends in enterprises, with a focus on its impact on the healthcare and legal…

This Week in Startups is brought to you by… Ramp. The corporate card and spend management software designed to help you save time and money. Get $250 when you join Ramp today at https://www.ramp.com/twist. DevSquad. Most dev agencies only offer developers. Why? Because product management is hard. Get an entire product team for the cost of one US developer plus 10% off at http://devsquad.com/twist. Digital Ocean. Whether you're just getting started with AI, or seeing your project take off, DigitalOcean is the cloud platform that lets you focus on what matters: building killer apps. Right now get up to $100k in free credits at https://www.do.co/twist. Terms and conditions apply. * Todays show: Jason and Alex kick off the show with a deep dive into Nvidia's blowout earnings and the skyrocketing demand for its upcoming Blackwell chips. Meanwhile, Google's search monopoly took center stage as proposed remedies, including a potential Chrome divestment, sparked heated debate. To unpack the implications, Brave's…

This Week in Startups is brought to you by… Vanta. Compliance and security shouldn't be a deal-breaker for startups to win new business. Vanta makes it easy for companies to get a SOC 2 report fast. TWiST listeners can get $1,000 off for a limited time at https://www.vanta.com/twist OpenPhone. Create business phone numbers for you and your team that work through an app on your smartphone or desktop. TWiST listeners can get an extra 20% off any plan for your first 6 months at https://www.openphone.com/twist⁠ Sprig. The Product Experience platform that generates AI-powered opportunities to continuously improve your product at scale. Visit https://www.sprig.com/twist to book a demo and get a $75 gift card. * Todays show: Jason and Alex dig into why Nvidia's latest earnings report is such a big deal, and how the chip giant could help keep the AI hype alive. Or, how it could poke a hole in market enthusiasm. The pair also welcome the CEO of Allen Control Systems to discuss building venture-backed defense…

Todays show: Spenser Skates and James Evans join Alex to discuss Amplitude's acquisition of Command AI, shedding light on recent startup M&A trends and the strategic vision behind this move. The conversation delves into Command AI's user assistance technology and its integration into Amplitude, which aims to enhance user surveys and feedback. Spenser outlines Amplitude's product-led growth strategy and its approach to scaling through acquisitions while managing risks and ensuring cultural alignment. The discussion also covers the acquisition deal structure, regulatory concerns, and the decision-making process between raising funds and selling. Also, we hear Spenser's unfiltered take on private equity and regulatory oversight! * Timestamps: (0:00) Spenser Skates of Amplitude & James Evans of CommandAI join Alex. (1:40) Startup M&A trends and Amplitude's acquisition of Command AI (4:30) Overview of Command AI's user assistance technology (7:05) Integration and benefits of Command AI within Amplitude (10:17)…

This Week in Startups is brought to you by… Coda. A new doc that brings words, tables and teams together. All your valuable data, plans, objectives, and strategies in one place. Go to https://www.coda.io/twist to get a $1,000 credit! Lemon.io - Hire pre-vetted remote developers, get 15% off your first 4 weeks of developer time at https://Lemon.io/twist Kyte. Looking to get out of the city? Rent a car with Kyte. Kyte delivers rental cars to your door. No counter, no lines, no hassle. Download the Kyte app today and use code JASON to save 10% on your first rental. * Todays show: Alex Wilhelm joins Jason to discuss Netflix's 'fight' night, exploring content rights, media models, and the fragmentation of sports. They then covered Brendan Carr's promotion to FCC chair, a win for satellite Internet but raising concerns about business interference. The conversation shifted to global social media regulation before examining the tech community's excitement about Emil Michael potentially leading the Department of…

This Week in Startups is brought to you by… LinkedIn Jobs. A business is only as strong as its people, and every hire matters. Go to https://www.linkedin.com/twist to post your first job for free. Terms and conditions apply. Beehiiv. Power your newsletters with AI tools, referral programs, and ad network features—all in one platform. Get 30 days free and 20% off your first 3 months at https://www.beehiiv.com/twist CLA. Innovation takes balance. CLA's CPAs, consultants, and wealth advisors can help you get from startup to where you want to end up. Get started now at https://www.CLAconnect.com/tech * Todays show: Altimeter's Jamin Ball joins Alex Wilhelm to discuss VC-founder dynamics, fund returns, rapid fundraising, and its impact on M&A. They cover public vs. private valuations, startup liquidity, AI's influence, SaaS trends, and Jamin's outlook on IPOs and exits. * Timestamps: (0:00) Jamin joins Alex to kick off the show (6:30) Alignment of incentives between VCs and founders (10:25) LinkedIn Jobs - Post…

This Week in Startups is brought to you by… Fundrise provides access to diversified portfolios of private real estate to all investors with their industry leading, easy to use platform. Sign up today at https://www.fundrise.com/TWIST OpenPhone. Create business phone numbers for you and your team that work through an app on your smartphone or desktop. TWiST listeners can get an extra 20% off any plan for your first 6 months at https://www.openphone.com/twist Linear. Linear helps product teams focus on what they do best: Planning and building great products. Streamline issues, projects, and product roadmaps in a tool your team will actually enjoy using. Get 25% off at https://www.linear.app/twist * Todays show: Jason and Alex host Phil Deutch, CEO of NGP Energy Tech Partners, to discuss solar power's potential in the energy crunch fueled by data center growth. They then explored the FBI's raid on Polymarket's CEO, and wrapped up with Y Combinator's latest startup requests, including Alex's space venture dreams…

This Week in Startups is brought to you by… Squarespace. Turn your idea into a new website! Go to https://www.Squarespace.com/TWIST for a free trial. When you're ready to launch, use offer code TWIST to save 10% off your first purchase of a website or domain. Lemon.io - Hire pre-vetted remote developers, get 15% off your first 4 weeks of developer time at https://Lemon.io/twist Sprig. The Product Experience platform that generates AI-powered opportunities to continuously improve your product at scale. Visit https://www.sprig.com/twist to book a demo and get a $75 gift card. * Timestamps: (0:00) Jason and Alex kick off the show (2:40) VATN Systems' Nelson Mills joins the show (4:01) The Torsk and its applications, focusing on defense and cost efficiency (7:23) Product velocity, military drone usage, and vehicle speed and depth capabilities (10:48) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST (12:01) Discussion on Chinese…

This Week in Startups is brought to you by… Beehiiv. Power your newsletters with AI tools, referral programs, and ad network features—all in one platform. Get 30 days free and 20% off your first 3 months at https://www.beehiiv.com/twist Vanta. Compliance and security shouldn't be a deal-breaker for startups to win new business. Vanta makes it easy for companies to get a SOC 2 report fast. TWiST listeners can get $1,000 off for a limited time at https://www.vanta.com/twist Cloud Devs. Building the best remote team is tough, but you don't have to do it alone. Visit https://www.clouddevs.com/twist for an unbeatable offer on hiring elite Latam talent today. * Todays show: Alex Wilhelm joins Jason to discuss Serve Robotics' self-driving robots, delivery economics, and building while public with CEO Ali Kashani. Then, the pair dug into high-skill immigration under the upcoming administration and massive price gains in stocks and crypto assets. Alex wondered if the stock market isn't overvalued, full-stop, but both…

This Week in Startups is brought to you by… Runway. Looking to up-level your financial planning Runway is the modern and intuitive way to model, plan, and align your business for everyone on your team. Sign up at https://www.runway.com/twist to get your first 3 months free. LinkedIn Ads. To redeem a $100 LinkedIn ad credit and launch your first campaign, go to https://www.linkedin.com/thisweekinstartups⁠⁠ Vanta. Compliance and security shouldn't be a deal-breaker for startups to win new business. Vanta makes it easy for companies to get a SOC 2 report fast. TWiST listeners can get $1,000 off for a limited time at https://www.vanta.com/twist * Todays show: Alex Wilhelm joins Jason to discuss Apple's on-device AI and its privacy implications, Reddit's earnings, and Amazon's multi-billion dollar investment interest in Anthropic with strategic chip conditions. They also discuss economic indicators like inflation's impact on voter sentiment and what metrics will define success for the next administration.…

This Week in Startups is brought to you by… Oracle. Oracle Cloud Infrastructure, or OCI, is a single platform for your infrastructure, database, application development, and AI needs. Save up to 50% on your cloud bill at ⁠https://w⁠⁠⁠⁠ww.oracle.com/twist Notion. Notion combines your notes, docs, and projects into one beautifully designed space with AI built right in. Try it for free today at https://notion.com/twist AssemblyAI. Get maximum value from voice data with AssemblyAI. Build powerful products and features for your end users on the industry's leading speech-to-text models. Get 100 free hours to start building at https://www.assemblyai.com/twist * Timestamps: (0:00) Jason and Alex kick off the show (3:55) Skydio's Adam Bry joins the show (4:22) Overview of Skydio's autonomous drones and public safety applications (9:31) Oracle - Try OCI and save up to 50% on your cloud bill at https://w⁠⁠⁠⁠ww.oracle.com/twist (11:07) Skydio as the largest US drone producer and Chinese sanctions impact (17:36) Risks of…

This Week in Startups is brought to you by: NetSuite. The number one cloud financial system, bringing accounting, financial management, inventory, and HR, into one platform. Giving you one source of truth. Download the CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist Gusto. Gusto is easy online payroll, benefits, and HR built for modern small businesses. Get three months free when you run your first payroll at https://www.gusto.com/twist *Gusto pricing shown in ad is based on pricing prior to March 2025 Washington Post. Stay informed with trusted journalism from The Washington Post. Right now, TWiST listeners can subscribe for just 50 cents per week for your first year at https://www.washingtonpost.com/twist * Todays show: In this episode, host Alex sits down with Exowatt's Hannan Parvizian to explore how the company is addressing the massive energy demands of AI and datacenters. They discuss Exowatt's mission to deliver affordable, sustainable power solutions that meet the…

This Week in Startups is brought to you by… Squarespace. Turn your idea into a new website! Go to https://www.Squarespace.com/twist for a free trial. When you're ready to launch, use offer code TWIST to save 10% off your first purchase of a website or domain. OpenPhone. Create business phone numbers for you and your team that work through an app on your smartphone or desktop. TWiST listeners can get an extra 20% off any plan for your first 6 months at https://www.openphone.com/twist Lemon.io. Hire pre-vetted remote developers, get 15% off your first 4 weeks of developer time at https://www.Lemon.io/twist * Todays show: Alex Wilhelm joins Jason to discuss AI's role in gaming with Decart's AI-generated video game and its potential impact.(10:31) Viral growth strategies for startups and Runway AI's video creation innovations. Financial topics include NVIDIA's market value and Amazon's nuclear power ambitions.(21:39). * Timestamps: (0:00) Jason and Alex kick off the show (3:34) Election security in America and…

This Week in Startups is brought to you by: Fidelity Private Shares℠. Manage your cap table and data room, get faster, more accurate 409A valuation and fully automate your next financing round. Visit ⁠https://fidelityprivateshares.com⁠! Mention our podcast and receive 20% off your first-year paid subscription. LinkedIn Jobs. A business is only as strong as its people, and every hire matters. Go to https://www.linkedin.com/twist to post your first job for free. Terms and conditions apply. Oracle - Oracle Cloud Infrastructure, or OCI, is a single platform for your infrastructure, database, application development, and AI needs. Save up to 50% on your cloud bill at ⁠https://w⁠⁠⁠⁠ww.oracle.com/twist * Timestamps: (0:00) Jason and Alex kick off the show (4:49) Extend Robotics' Dr. Chang Liu joins the show (6:23) The challenges of real-world automation, robotic grape picking, and human in the loop AI (10:44) Fidelity Private Shares℠ - Visit https://www.fidelityprivateshares.com Mention our podcast and receive 20%…

This Week in Startups is brought to you by: OpenPhone - Create business phone numbers for you and your team that work through an app on your smartphone or desktop. TWiST listeners can get an extra 20% off any plan for your first 6 months at https://www.openphone.com/twist Lemon.io - Hire pre-vetted remote developers, get 15% off your first 4 weeks of developer time at https://www.Lemon.io/twist Linear - Linear helps product teams focus on what they do best: Planning and building great products. Streamline issues, projects, and product roadmaps in a tool your team will actually enjoy using. Get 25% off at https://www.Linear.app/twist * Todays show: Moniepoint made waves this week by raising a massive $110 million Series C. For a startup in a category (fintech) that has seen its venture fortunes falter and a company building for the African market (which has seen its venture inflows slow), Moniepoint is an outlier – twice. Three times if you consider how quickly the company has grown in recent years. How did…

This Week in Startups is brought to you by: Vanta. Compliance and security shouldn't be a deal-breaker for startups to win new business. Vanta makes it easy for companies to get a SOC 2 report fast. TWiST listeners can get $1,000 off for a limited time at https://www.vanta.com/twist Squarespace. Turn your idea into a new website! Go to https://www.Squarespace.com/TWIST for a free trial. When you're ready to launch, use offer code TWIST to save 10% off your first purchase of a website or domain. Kalshi. Kalshi—the largest regulated predictions market—now lets you trade on US elections. Visit https://www.kalshi.com/twist to see live odds, trade, and get $20 when you deposit $100. * Todays show: Alex Wilhelm interviews leaders from Monte Carlo and Mastertech.ai, exploring their roles in data observability and AI applications. Linda Gray shares her journey founding Mastertech.ai and highlighting AI's transformative role in auto shops.(2:05) Monte Carlo's Lior Gavish discusses the importance of data downtime and…

This Week in Startups is brought to you by… Digital Ocean. Whether you're just getting started with AI, or seeing your project take off, DigitalOcean is the cloud platform that lets you focus on what matters: building killer apps. Right now get up to $100k in free credits at https://do.co/twist Terms and conditions apply. Cloud Devs. Building the best remote team is tough, but you don't have to do it alone. Visit https://www.clouddevs.com/twist for an unbeatable offer on hiring elite Latam talent today. Kalshi. Kalshi the largest regulated predictions market—now lets you trade on US elections. Visit https://www.kalshi.com/twist to see live odds, trade, and get $20 when you deposit $100. * Todays show: Sonos director Mattias Scheek joins Jason & Alex to discuss his journey in audio technology and Sonos acquisition. Then, Jason and Alex dive into election security (34:57), influencer marketing, Google's upcoming AI release (1:10:42), and more! * Timestamps: (0:00) Jason and Alex kick off the show (3:18)…

In this episode: Alex talks with Shensi Ding from Merge, who shares her transition from finance to tech and highlights the critical role of integrations in modern businesses. They explore the challenges of building and maintaining these integrations, emphasizing the importance of standardized data models. Shensi discusses partnerships and the strategies to overcome resistance. The conversation delves into trust-building, enhancing integration observability, and expanding Merge's offerings to include AI applications. They also touch on financial efficiency, growth strategies, and Merge's evolution beyond APIs, concluding with insights into future plans and potential acquisition interest. * Timestamps: (0:00) Alex kicks off the show with guest Shensi Ding of Merge. (5:18) Shensi's journey from finance to tech and the importance of integrations (10:20) The challenges of building and maintaining integrations (11:19) Coda. Empower your startup with Coda's Team plan for free—get 6 months at…

In this episode we look back at all the Jam with JCal sessions from 2024. This is where startups pitch their groundbreaking ideas to Jason, covering everything from AI-driven investor tools and gamified publisher rewards to sleep tech and architecture compliance software. Watch as these innovative founders get unfiltered feedback and game-changing advice! Don't miss these exciting pitches that could be the next big thing. * Timestamps: (0:00) Alex kicks off the show, setting the stage for our "Jam with JCal" season recap, focusing on startups using .TECH domains. (0:53) Jason discusses the origins of the Jam with JCal sessions and how Travis from Uber inspired the format. (1:39) Ramsey Shaffer presents Uptrends AI, explaining how it helps financial advisors manage and stay ahead of market news. (17:24) Ana Malhotra introduces Rome, a yard-sharing service for dogs. (32:24) Tyce Herrman talks about Ullama, software for architects that analyzes 3D building models for code compliance, highlighting their journey…

This Week in Startups is brought to you by… LinkedIn Ads. To redeem a $100 LinkedIn ad credit and launch your first campaign, go to https://www.linkedin.com/thisweekinstartups Vanta. Compliance and security shouldn't be a deal-breaker for startups to win new business. Vanta makes it easy for companies to get a SOC 2 report fast. TWiST listeners can get $1,000 off for a limited time at https://www.vanta.com/twist Beehiiv. Power your newsletters with AI tools, referral programs, and ad network features—all in one platform. Get 30 days free and 20% off your first 3 months at https://www.beehiiv.com/twist * Todays show: Jason and Alex dive into the latest updates from Claude AI, exploring the new "Use Computer" feature and its implications. Next, Andrew Lissimore of headphones.com shares the journey of turning a side hustle into a thriving business, highlighting the advantages of owning a premium domain and leveraging YouTube for customer acquisition. The team from Prandtl Dynamics then joins to showcase their…

This Week in Startups is brought to you by… Squarespace. Turn your idea into a new website! Go to https://www.Squarespace.com/TWIST for a free trial. When you're ready to launch, use offer code TWIST to save 10% off your first purchase of a website or domain. LinkedIn Jobs. A business is only as strong as its people, and every hire matters. Go to https://www.linkedin.com/twist to post your first job for free. Terms and conditions apply Kalshi. The largest regulated predictions market—now lets you trade on US elections. Visit kalshi.com/twist to see live odds, trade, and get $20 when you deposit $100. * Timestamps: (0:00) Jason and Alex kick off the show (4:10) Heritage Foundation's stance on election integrity and fraud (11:18) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST (12:48) Technological improvements for secure elections (21:07) Hans von Spakovsky's perspective on the 2020 election (22:29) LinkedIn Ads - Get a $100…

This Week in Startups is brought to you by… DigitalOcean's GPU Droplet - simple flexible, affordable, and scalable machines for your AI/ML workloads. Spin up powerful GPU virtual machines and start training models, building agents, or digging deep into huge data sets in seconds—and spin them back down just as quickly. With options ranging from single-GPU configurations to setups with 8 GPUs, you can scale computing power based on your specific needs without having to make upfront hardware investments. Get up to 100k in free Credits at https://www.do.co/twist⁠! Oracle - Oracle Cloud Infrastructure, or OCI, is a single platform for your infrastructure, database, application development, and AI needs. Save up to 50% on your cloud bill at ⁠https://w⁠⁠⁠⁠ww.oracle.com/twist Kalshi—the largest regulated predictions market—now lets you trade on US elections. Visit https://www.kalshi.com/twist to see live odds, trade, and get $20 when you deposit $100. * Todays show: Alex Wilhelm joins Jason to discuss the GPU market…