Neurology Minute

Dr. Jason Crowell and Dr. John McDonough discuss the historical and economic factors shaping the US healthcare system and why understanding these systemic forces matters for neurologists and patient care. Show citation: Powell A. How to fix U.S. Healthcare? "Radical Action," says John McDonough. Harvard Gazette. August 18, 2026. Accessed August 20, 2026. https://news.harvard.edu/gazette/story/2026/08/how-to-fix-u-s-healthcare-radical-action-says-john-mcdonough/.

In the eighth episode of this nine-part series, Dr. Christine Cliatt-Brown discusses delusional companion syndrome.

In the seventh episode of this nine-part series, Dr. Christine Cliatt-Brown discusses reduplicative paramnesia.

In the sixth episode of this nine-part series, Dr. Christine Cliatt-Brown discusses Cotard syndrome.

Dr. Shuvro Roy and Dr. Daniel Daneshvar discussed the prevalence of CTE at death among NFL players and the association between CTE severity and the risk of dementia. Show citation: Daneshvar DH, Nowinski CJ, Abdolmohammadi B, et al. Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21. BMJ. 2026;394:e100418. Published 2026 Aug 25. doi:10.1136/bmj-2026-100418

Dr. Kait Nevel and Dr. Katharina Schmidbauer discuss primary CNS T-cell lymphoma, highlighting diagnostic challenges, imaging characteristics, and treatment approaches for this rare disease. Show citation: Schmidbauer KJ, Karschnia P, Kaulen LD, et al. Clinical Manifestations of Primary CNS T-Cell Lymphoma: A Retrospective Study of Histopathologic, Molecular, and Neuroimaging Features. Neurol. 2026;106(7):e214744. Published 2026 Mar 17. doi:10.1212/WNL.0000000000214744

In the October episode of the President's Spotlight, Dr. Jason Crowell and Dr. Natalia Rost discuss updates on membership options that will help more neurology professionals connect with the AAN. Stay informed by watching the President's Spotlight video.

In part two of this series, Dr. Dara Albert and Dr. Bruce Cohen highlight the most important takeaways from the task force findings. Show citation: Cohen BH, Gilbert DL, Xixis K, et al. Education Research: The Future of Child Neurology Residency Training: The Perspective of a Child Neurology Society Task Force. Neurol Educ. 2026;5(2):e200331. Published 2026 Jun 12. doi:10.1212/NE9.0000000000200331

In the second episode of this two-part series, Dr. Tesha Monteith and Dr. Tamara Pringsheim discuss key take-home messages from the guideline recommendations and share insights on integrating them into clinical practice. Show citation: Potrebic S, Tanveer S, Becker WJ, et al. Pharmacologic Treatment for Migraine Prevention in Adults Practice Guideline Recommendations: Report of the AAN Guidelines Subcommittee and the American Headache Society. Headache. Published online August 31, 2026. doi:10.1111/head.70199

In part one of this series, Dr. Dara Albert and Dr. Bruce Cohen discuss why the Child Neurology Society felt it was important to establish a task force to examine child neurology training at this point in time. Show citation: Cohen BH, Gilbert DL, Xixis K, et al. Education Research: The Future of Child Neurology Residency Training: The Perspective of a Child Neurology Society Task Force. Neurol Educ. 2026;5(2):e200331. Published 2026 Jun 12. doi:10.1212/NE9.0000000000200331

In the first part of this two-part series, Dr. Tesha Monteith and Dr. Tamara Pringsheim provide a brief overview of the guideline recommendations for pharmacologic treatment of migraine prevention in adults. Show citation: Potrebic S, Tanveer S, Becker WJ, et al. Pharmacologic Treatment for Migraine Prevention in Adults Practice Guideline Recommendations: Report of the AAN Guidelines Subcommittee and the American Headache Society. Headache. Published online August 31, 2026. doi:10.1111/head.70199

In the fifth episode of this nine-part series, Dr. Christine Cliatt-Brown discusses syndrome of subjective doubles.

In the fourth episode of this nine-part series, Dr. Christine Cliatt-Brown discusses mirrored self-misidentification syndrome.

In the third episode of this nine-part series, Dr. Christine Cliatt-Brown discusses Fregoli syndrome.

Dr. Justin Abbatemarco and Dr. Irene Cortese discuss recent advances in the treatment of progressive multifocal leukoencephalopathy (PML), focusing on immune-based therapies like virus-specific T cells and immune checkpoint inhibitors. Show citation: Gonzalez CE, Fletcher A, Jenkins TL, et al. Resolution of PML after Treatment with Virus-Specific T Cells and HCT. N Engl J Med. 2026;394(20):2061-2064. doi:10.1056/NEJMc2514186

Dr. Kait Nevel and Drs. Ayal Aizer and Clara Baselga-Garriga discuss the link between primary motor cortex involvement in brain metastases and increased seizure risk. Show citation: Baselga-Garriga C, Purohit S, Lamba N, et al. Primary Motor Cortex Involvement and Its Association With Seizure Risk in Patients With Brain Metastases. Neurology. 2026;106(7):e214714. doi:10.1212/WNL.0000000000214714

In part two of this nine-part series, Dr. Christine Cliatt-Brown discusses Capgras syndrome.

In part one of this nine-part series, Dr. Christine Cliatt-Brown provides an overview of delusional misidentification syndromes.

In the final episode of this series, Dr. Paul Crane and Dr. Prashanth Ramachandran discuss the complex role of TNF alpha inhibition in tuberculosis treatment and the use of infliximab and other targeted therapies to manage inflammation.

In this episode, Dr. Jose Posas reviews the Capitol Hill Report from September 7th, discussing the busy month ahead for Congress, BrainPAC, and a couple of other advocacy news items. Stay updated with what's happening on the hill by visiting aan.com/chr. Learn how you can get involved with AAN advocacy.

In part two of this series, Dr. Aaron Zelikovich and Dr. Bhaskar Roy discuss recommendations to help neurologists navigate the expanding landscape of myasthenia gravis treatments. Show citation: McLaren NP, Rosati M, Zhong W, et al. Comparison of the Efficacy and Safety of Myasthenia Gravis Treatments: A Bayesian Network Meta-Analysis. Neurology. 2026;107(3):e218351. doi:10.1212/WNL.0000000000218351

In the second episode of this series, Dr. Justin Abbatemarco and Dr. Sara Marceglia discuss the risks of incorporating AI into clinical practice. Show citation: Vozzi C, Sibilla M, Sandri D, et al. Education Research: Bridging the Artificial Intelligence Training Gap: Evidence from a National Survey of Italian Neurology Residents. Neurol Educ. 2026;5(1):e200289. Published 2026 Jan 27. doi:10.1212/NE9.0000000000200289

In the sixth episode of this series, Dr. Paul Crane and Dr. Prashanth Ramachandran discuss high-dose rifampin in TB meningitis.

In part one of this series, Dr. Justin Abbatemarco and Dr. Alberto Priori discussed the use of artificial intelligence in neurology among peers, not just trainees. Show citation: Vozzi C, Sibilla M, Sandri D, et al. Education Research: Bridging the Artificial Intelligence Training Gap: Evidence from a National Survey of Italian Neurology Residents. Neurol Educ. 2026;5(1):e200289. Published 2026 Jan 27. doi:10.1212/NE9.0000000000200289

In the September episode of the President's Spotlight, Dr. Jason Crowell and Dr. Natalia Rost discuss BrainHealth.com and the AAN's expanding brain health movement. Stay informed by watching the President's Spotlight video.

In the fifth episode of this series, Dr. Paul Crane and Dr. Prashanth Ramachandran discuss dexamethasone and listeria meningitis.

In the fourth episode of this series, Dr. Paul Crane and Dr. Prashanth Ramachandran discuss the use of dexamethasone in the treatment of pneumococcal meningitis.

In the first installment of this series, Dr. Aaron Zelikovich and Dr. Bhaskar Roy discuss how emerging treatments for myasthenia gravis compare to one another. Show citation: McLaren NP, Rosati M, Zhong W, et al. Comparison of the Efficacy and Safety of Myasthenia Gravis Treatments: A Bayesian Network Meta-Analysis. Neurology. 2026;107(3):e218351. doi:10.1212/WNL.0000000000218351

Dr. Jason Crowell and Ka-Ho Wong discuss national trends in Medicare reimbursement for inpatient neurologic care. Show citation: Wong KH, Castillo M, King J, et al. National Trends in Medicare Charges and Reimbursement for Inpatient Neurologic Care, 2013-2023. Neurology. 2026;107(6):e218460. doi:10.1212/WNL.0000000000218460

In the third episode of this series, Dr. Paul Crane and Dr. Prashanth Ramachandran discuss HSV encephalitis and dexamethasone.

In part two of this series, Dr. Paul Crane and Dr. Prashanth Ramachandran discuss pegivirus-associated encephalomyelitis.

In part one of this series, Dr. Paul Crane and Dr. Prashanth Ramachandran discuss acute necrotizing encephalopathy.

In part one of this series, Drs. Greg Cooper, Trey Bateman, and Gregg Day discussed key takeaways from the 2026 Alzheimer's Association International Conference, focusing on blood-based biomarkers, anti-amyloid therapies, and other important highlights.

Dr. Justin Abbatemarco recaps a presentation on Hashimoto encephalopathy from the AAN Autoimmune Neurology Conference. Show citation: Valencia-Sanchez C, Pittock SJ, Mead-Harvey C, et al. Brain dysfunction and thyroid antibodies: autoimmune diagnosis and misdiagnosis. Brain Commun. 2021;3(2):fcaa233. Published 2021 Jan 5. doi:10.1093/braincomms/fcaa233 Brain, Jellinek E, Ball K HASHIMOTO'S DISEASE AND ENCEPHALOPATHY The Lancet, 288, 512-514 Mattozzi S, Sabater L, Escudero D, et al. Hashimoto encephalopathy in the 21st century. Neurology. 2020;94(2):e217-e224. doi:10.1212/WNL.0000000000008785

In this lab minute, Dr. Stacey Clardy reviews the role of vitamin B12 testing in neurologic practice.

In part two of this series, Dr. Dara Albert and Dr. Daniel Freedman discuss key unanswered questions in infantile epilepsy and future research priorities. Show citation: Freedman D, Babatunde I, Morgan RL, et al. American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy. Epilepsy Curr. 2026;26(3):174-202. Published 2026 Apr 8. doi:10.1177/15357597261433266

Dr. Shuvro Roy and Prof. Catherine Jutzeler discussed how age influences neurologic and functional recovery after spinal cord injury and how these findings could inform treatment and future clinical trials. Show citation: Pavese C, Scivoletto G, Puci M, et al. The Relationship Between Age and Recovery After Spinal Cord Injury: A Longitudinal Cohort Study. Neurology. 2026;106(2):e214516. doi:10.1212/WNL.0000000000214516

Dr. Greg Cooper and Dr. Chloe Hill discuss comparing virtual and in-person neurology outpatient visits for new patients. Show citation: Hill CE, Lin CC, Harris A, et al. Virtual vs In-Person Neurologic Ambulatory Care: A Case-Control Study of Subsequent Health Care Utilization. Neurology. 2026;106(10):e214989. doi:10.1212/WNL.0000000000214989

In this lab minute, Dr. Stacey Clardy discusses Tolosa Hunt syndrome

Dr. Margarita Fedorova talks with Dr. Sunanjay Bajaj about the Consortium of Neurology Residents and Fellows (CNRF). Visit the AAN website to learn more about the CNRF. Connect with the AAN's Consortium of Neurology Residents and Fellows on Synapse.

Dr. Aaron Zelikovich discusses the efficacy and anthropometric effect of vamorolone with prednisone and deflazacort. Show citation: Clemens PR, Berglund A, Schiava M, et al. Vamorolone for Duchenne Muscular Dystrophy: A Cross-Trial Efficacy Comparison With Classic Corticosteroids From the FOR-DMD Trial. Neurology. 2026;107(1):e214756. doi:10.1212/WNL.0000000000214756

In part one of this series, Dr. Dara Albert and Dr. Daniel Freedman share their key takeaways from the recent guideline. Show citation: Freedman D, Babatunde I, Morgan RL, et al. American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy. Epilepsy Curr. 2026;26(3):174-202. Published 2026 Apr 8. doi:10.1177/15357597261433266

Dr. Jessica Ailani and Dr. Serena Orr discuss the genetic risk of migraine and post-traumatic headache in children. Show citation: Orr SL, Hershey AD, Kurowski BG, et al. Post-Traumatic Headache in Children and Genetic Risk of Migraine: An Observational Cohort Study. Neurol Genet. 2026;12(2):e200371. Published 2026 Apr 1. doi:10.1212/NXG.0000000000200371

Dr. Aaron S. Zelikovich discusses the phase 3 NIMBLE trial of cemdisiran, an siRNA targeting complement component 5, for the treatment of generalized myasthenia gravis. Show citation: Vu T, Habib AA, Jacob S, et al. Efficacy and safety of cemdisiran siRNA in myasthenia gravis (NIMBLE): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet. 2026;407(10540):1712-1725. doi:10.1016/S0140-6736(26)00690-2

Dr. Zohaib Siddiqi shares clinical pearls on negative myoclonus.

Dr. Margarita Fedorova discusses the use of troriluzole for spinocerebellar ataxia. Show citations: https://www.neurology.org/doi/10.1212/WNL.0000000000209018 https://clinicaltrials.gov/study/NCT06034886 https://clinicaltrials.gov/study/NCT02960893

Drs. Paul Crane, Fiifi Duodu, and Malya Sahu discuss neuroimmunology and multiple sclerosis diagnosis in Africa, including challenges and efforts to improve care. Show citation: Sahu M, Chomba M, Duodu F, Diaz MM, Sokhi D, Saylor D. The Current State of Diagnostics for Neuroimmunological Disorders in Africa. J Cent Nerv Syst Dis. 2025;17:11795735251385319. Published 2025 Nov 19. doi:10.1177/11795735251385319

Dr. Elizabeth Coon and Dr. Lucy Norcliffe-Kaufmann discuss the mechanism-based therapy with ampreloxetine for neurogenic orthostatic hypotension in multiple system atrophy, highlighting recent clinical trial results and future directions. Show citation: Freeman R, Kaufmann H, Biaggioni I, et al. Mechanism-Based Therapy With Ampreloxetine for Neurogenic Orthostatic Hypotension in Multiple System Atrophy: A Randomized Withdrawal Trial. Neurology. 2026;107(3):e218284. doi:10.1212/WNL.0000000000218284

Dr. Margarita Fedorova explores sex-related differences in the pharmacokinetics of levodopa among levodopa-naïve patients with PD and evaluates their relationships with levodopa-related complications. Show citation: Conti V, De Bellis E, Corbi G, et al. Sex differences in levodopa pharmacokinetics in early Parkinson's disease: implications on levodopa-related complications. Front Pharmacol. 2026;17:1748932. Published 2026 Apr 7. doi:10.3389/fphar.2026.1748932

In part two of this series, Dr. Halley Alexander and Dr. Heidi Munger Clary discuss the steps to take if you are screening for a psychiatric comorbidity and the results indicate that someone may be positive for depression, anxiety, or another condition. Show citations: Mula M, Brodie MJ, de Toffol B, et al. ILAE clinical practice recommendations for the medical treatment of depression in adults with epilepsy. Epilepsia. 2022;63(2):316-334. doi:10.1111/epi.17140 Patel AD, Baca C, Franklin G, et al. Quality improvement in neurology: Epilepsy Quality Measurement Set 2017 update. Neurology. 2018;91(18):829-836. doi:10.1212/WNL.0000000000006425